Genomic variants-driven drug repurposing for tuberculosis by utilizing the established bioinformatic-based approachShort communication Published on 2022-12-012022-10-05 Journal: Biochemistry and Biophysics Reports [Category] 신약개발, [키워드] annotations applied approach bioinformatics biological process CCR5 CD44 cellular component contribute CXCR4 demonstrated deregulation disease disease-associated drug Drug discovery Drug repurposing drug target evaluated Evidence facilitate functional functional annotation Genes genomic genomic variant genomic variants GWAS HLA-B identify implementation in-silico indication involved KEGG Missense mutation molecular overlapped Pathogenesis Pathway analysis provided risk SELP suggested target Treatment Tuberculosis variant [DOI] 10.1016/j.bbrep.2022.101334 [Article Type] Short communication
The Integral Membrane Protein ZMPSTE24 Protects Cells from SARS-CoV-2 Spike-Mediated Pseudovirus Infection and Syncytia FormationArticle Published on 2022-10-262022-11-15 Journal: mBio [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] acute respiratory syndrome appear assays catalytic caused Cell cell-cell fusion cell-cell fusion assay cells cellular cellular component cellular membrane contribute coronavirus coronavirus coronavirus SARS-CoV-2 Coronaviruses COVID-19 COVID-19 pandemic dead defend Defense Efficiency ENhance entry of SARS-CoV-2 examined Formation genetic knockout global public health host cell membranes IFITM IFITMs in viral include Infection inhibiting inhibitory activity innate immune innate immune response Integral interact Interaction interfere intrinsic knockdown lentivirus maturation mechanism membrane membrane protein MHV mouse hepatitis virus nuclear overexpression pandemic Plaque assay precursor prelamin A Prevent protease Proteases PROTECT Protective protective role Protein proteolytic proteolytic activity reduce required restriction factor restriction factor. SARS-CoV-2 SARS-CoV-2 pseudovirus infection shown spike Therapeutic benefit transmembrane protein viral infection viral infections virus virus entry viruses wild-type ZMPSTE24 [DOI] 10.1128/mbio.02543-22 PMC 바로가기
Immunological memory to SARS-CoV-2 infection and COVID-19 vaccinesArticle Published on 2022-09-012022-11-15 Journal: Immunological reviews [Category] COVID19(2023년), SARS, 진단, [키워드] acute infectious disease adaptive immune system adenoviral vectors anatomical antibodies antibody B cells CD4 T cells CD8 T cells cellular cellular component coronavirus COVID-19 COVID-19 vaccine COVID-19 vaccines cross-sectional develop Extraordinary feature Head-to-head comparison help Hybrid immunity immune memory Infection infections knowledge long-lasting memory memory B memory B cells memory T memory T cells mRNA mRNA vaccines natural immunity other diseases protective immunity Protein protein vaccine. provided Quantitative responses SARS-CoV-2 SARS-COV-2 infection Vaccine Vaccines [DOI] 10.1111/imr.13089 PMC 바로가기
Bioinformatics analysis of potential common pathogenic mechanisms for COVID-19 infection and primary Sjogren’s syndromeCOVID-19 감염 및 원발성 쇼그렌 증후군에 대한 잠재적인 일반적인 병원성 메커니즘의 생물정보학 분석Article Published on 2022-07-262022-09-11 Journal: Frontiers in Immunology [Category] 유전자 메커니즘, [키워드] analysis Analysis CDCA2 cellular component cellular components CMPK2 COVID-19 COVID-19 infection cytoHubba database DEGs diagnostic Diagnostic markers differentially expressed differentially expressed gene Differentially expressed genes downloaded Evidence functional annotation Gene Expression Omnibus gene expression profile Gene expression profiles gene regulatory network General population Genes GEO HERC5 hub genes Ifi44 IFI44L IFIT1 IFIT2 IFIT3 marker mechanism metabolic pathway metabolic pathways molecular mechanism molecular mechanisms MX1 participated Pathogenesis pathogenic mechanism pathway Patient performed PPI Prevalence primary Sjogren’s syndrome. progression protein-protein interaction regulatory network reveal RRM2 selected significantly higher Sjögren’s syndrome subsequent analyses syndrome TOP2A transcription factor TYMS [DOI] 10.3389/fimmu.2022.938837 PMC 바로가기 [Article Type] Article
Local and Systemic Immunity Are Impaired in End-Stage-Renal-Disease Patients Treated With Hemodialysis, Peritoneal Dialysis and Kidney Transplant Recipients Immunized With BNT162b2 Pfizer-BioNTech SARS-CoV-2 VaccineBNT162b2 화이자-바이오엔텍 SARS-CoV-2 백신을 접종한 혈액투석, 복막투석, 신장이식 환자 말기 신장질환 환자의 국소 및 전신 면역 손상Article Published on 2022-07-222022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] analyzed anti-S anti-S IgG antibodies antibody binding antibody unit BNT162b2 cellular component clinical control group COVID-19 COVID-19 in patient COVID-19 vaccine dose effective End-stage renal disease ESRD Guidance HD group healthy individual Hemodialysis high mortality rate highest IFN-γ IgA IgG Immunity Immunoglobulin G Impaired Interferon-gamma investigated kidney transplant recipient Local Messenger RNA MONITOR mRNA participant Patient patients performed Peritoneal dialysis Pfizer Pfizer-BioNTech positive produced recipient required Research Responder SARS-CoV-2 Seroconversion seroconversion rate seronegative patient seropositive subjects systemic tested therapy Transplant transplantation. Trial registration Vaccine vaccine response [DOI] 10.3389/fimmu.2022.832924 PMC 바로가기 [Article Type] Article
Assessment of T-cell Reactivity to the SARS-CoV-2 Omicron Variant by Immunized Individuals면역화된 개인에 의한 SARS-CoV-2 오미크론 변이체에 대한 T 세포 반응성 평가Article Published on 2022-04-012022-09-11 Journal: JAMA Network Open [Category] COVID19(2023년), SARS, 변종, [키워드] age assessment blood sample Blood samples Care CD4+ cell CD4+ cells CD4+ T cell CD4+ T cells CD8+ T cells Cell cellular component cellular immunity cohort study conducted contagious decrease determine enrolled foundation Frequency full-length protein group Health Health care highlight Hospitalization immune immune protection immune system Immunity immunized individual Infection Italy Lymphocytes median mutated Mutation Neutralizing new SARS-CoV-2 no significant differences omicron Omicron variant outcome participant peptide peptides reactive reactivity reduced reduction Region regions Rome SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant sera severe disease significant difference significantly Spike protein Stimulation T cells T-cell T-cell immunity tested the SARS-CoV-2 the spike protein vaccination variant variant of SARS-CoV-2 Volunteer volunteers women [DOI] 10.1001/jamanetworkopen.2022.10871 PMC 바로가기 [Article Type] Article
SARS-CoV-2: Receptor and Co-receptor Tropism ProbabilitySARS-CoV-2: 수용체 및 공동 수용체 방향성 확률Review Published on 2022-03-162022-09-11 Journal: Current microbiology [Category] SARS, 유전자 메커니즘, [키워드] ACE2 ACE2 distribution acute respiratory syndrome addition Amino acid amino acids angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 attachment binding broad spectrum caused cells cellular cellular component China Co-receptor coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 disease domain entry of SARS-CoV-2 extreme facilitate Factor first stage help heterogeneous Host host cell hosts humans infect mechanisms membrane molecular organs pandemic Pathogenesis pathogenesis of COVID-19 pathogenic virus Perspective Prevent protease Proteases public health RBD receptor Receptor-binding domain receptor-binding domains receptors required SARS-CoV-2 SARS-CoV-2 spike protein Severe acute respiratory syndrome Severe acute respiratory syndrome-related coronavirus Severe acute respiratory syndrome-related coronavirus-2 severity Spike protein Spike proteins susceptibilities the SARS-CoV-2 the spike protein tissues Treatment strategies tropism understanding virus entry [DOI] 10.1007/s00284-022-02807-7 PMC 바로가기 [Article Type] Review
Bioinformatics approach to identify common gene signatures of patients with coronavirus 2019 and lung adenocarcinoma코로나바이러스 2019 및 폐 선암종 환자의 공통 유전자 서명을 식별하기 위한 생물정보학 접근법Article Published on 2022-03-012022-09-11 Journal: Environmental science and pollution research inter [Category] MERS, 바이오마커, 유전자 메커니즘, 진단, [키워드] approach association bioinformatics biological process cells cellular component co-expressed commonality Coronavirus 2019 coronavirus disease Coronavirus disease 2019 correlation COVID-19 database dataset DEGs develop differentially expressed gene Differentially expressed genes Diseases enrichment analysis evaluate expressed Gene Expression Gene regulatory networks gene signature global pandemic Healthcare systems hub gene hub genes identify immune immune infiltration infected with COVID-19 lung adenocarcinoma lung cancer management Methylation molecular organs pathological mechanism Pathways Patient patients with COVID-19 platform PPI protein-protein interaction Regulatory reveal SARS-CoV-2 SARS-CoV-2. severe disease significantly Spearman transcription factor treating Treatment was obtained were used with COVID-19 [DOI] 10.1007/s11356-021-17321-9 PMC 바로가기 [Article Type] Article
Extracellular vimentin is an attachment factor that facilitates SARS-CoV-2 entry into human endothelial cells423 Published on 2022-01-252022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, COVID19(2023년), SARS, [키워드] A549 cell ACE2 Analysis angiotensin-converting enzyme 2 antibody bind binding blocked Cell cellular component Complication contribute CR3022 Endothelial cell endothelial cells Entry mechanism entry receptor enzyme epitope expressed expressing Extracellular facilitate filament protein HEK-293 cell HEK-293 cells host cell Human implication in viral inhibited Interaction knockdown lung neutralized Pathogenesis pathogenesis of COVID-19 performed Protein provide pseudotyped pseudotyped virus purified RBD Receptor binding domain recognize reduced S-protein S-RBD SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2-S Significance significantly the SARS-CoV-2 Transmission Vaccines Vascular VIM vimentin viral entry virus with COVID-19 [DOI] 10.1073/pnas.2113874119 PMC 바로가기 [Article Type] 423
Mutational Landscape and Interaction of SARS-CoV-2 with Host Cellular ComponentsReview Published on 2021-08-242022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] ACE2 receptor acute respiratory syndrome antiviral therapeutics cellular cellular component Characteristics combating component coronavirus coronavirus database effective Evolution examined Health Host host interaction humans impacted Increasing Interaction landscape MicroRNAs Mutation new SARS-CoV-2 non-structural protein Protein resource RNA RNA-binding proteins rRNA SARS-CoV-2 SARS-COV-2 infection small nuclear RNA snRNA structural proteins the SARS-CoV-2 the SARS-CoV-2 genome therapeutic therapeutic strategy therapy Vaccine Vaccine-induced immunity variant variants Viral protein viral strains virus [DOI] 10.3390/microorganisms9091794 PMC 바로가기 [Article Type] Review